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HIV kao lijek protiv raka?
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ultranova Offline
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HIV kao lijek protiv raka?

Doctors have treated only three leukemia patients, but the sensational results from a single shot could be one of the most significant advances in cancer research in decades. And it almost never happened.

In the research published Wednesday, doctors at the University of Pennsylvania say the treatment made the most common type of leukemia completely disappear in two of the patients and reduced it by 70 percent in the third. In each of the patients as much as five pounds of cancerous tissue completely melted away in a few weeks, and a year later it is still gone.

The results of the preliminary test “exceeded our wildest expectations,” says immunologist Dr. Carl June a member of the Abramson Cancer Center's research team.

Dr. Edgar Engleman, a cancer immunologist at Stanford University School of Medicine who was not involved in the research calls the results “remarkable ... great stuff.”

The Penn scientists targeted chroniclymphocytic leukemia (CLL), the most common type of the blood disease. It strikes some 15,000 people in the United States, mostly adults, and kills 4,300 every year. Chemotherapy and radiation can hold this form of leukemia at bay for years, but until now the only cure has been a bone marrow transplant. A bone marrow transplant requires a suitable match, works only about half the time, and often brings on severe, life-threatening side effects such as pain and infection.

In the Penn experiment, the researchers removed certain types of white blood cells that the body uses to fight disease from the patients. Using a modified, harmless version of HIV, the virus that causes AIDS, they inserted a series of genes into the white blood cells. These were designed to make to cells target and kill the cancer cells. After growing a large batch of the genetically engineered white blood cells, the doctors injected them back into the patients.

In similar past experimental treatments for several types of cancer the re-injected white cells killed a few cancer cells and then died out. But the Penn researchers inserted a gene that made the white blood cells multiply by a thousand fold inside the body. The result, as researcher June put it, is that the white blood cells became “serial killers” relentlessly tracking down and killing the cancer cells in the blood, bone marrow and lymph tissue.

As the white cells killed the cancer cells, the patients experienced the fevers and aches and pains that one would expect when the body is fighting off an infection, but beyond that the side effects have been minimal.

Doctors had told Bill Ludwig, one of the research volunteers, that he would die from his leukemia within weeks. Then he got the experimental treatment a year ago.

With tears welling up, he told NBC, "I'm more closer to the people I love and I appreciate them more... I'm getting emotional... the grass is greener and flowers smell wonderful."

The other two patients have chosen to remain anonymous but one who happens to be a scientist himself wrote, “I am still trying to grasp the enormity of what I am a part of -- and of what the results will mean to countless others with CLL or other forms of cancer. When I was a young scientist, like many I’m sure, I dreamed that I might make a discovery that would make a difference to mankind – I never imagined I would be part of the experiment.”

So why has this remarkable treatment been tried so far on only three patients?

Both the National Cancer Institute and several pharmaceutical companies declined to pay for the research. Neither applicants nor funders discuss the reasons an application is turned down. But good guesses are the general shortage of funds and the concept tried in this experiment was too novel and, thus, too risky for consideration.

The researchers did manage to get a grant from the Alliance for Cancer Gene Therapy, a charity founded by Barbara and Edward Netter after their daughter-in-law died of cancer. The money was enough to finance the trials on the first three patients.

With results for the three patients published Wednesday simultaneously in the New England Journal of Medicine and Science Translational Medicine, money for further studies -- not just in this one type of leukemia, but in other cancers -- will likely pour in from both the government and drug companies.

http://www.msnbc.msn.com/id/44090512


http://www.nejm.org/doi/full/10.1056/NEJMoa1103849


11-08-2011 10:56 PM
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Koder Offline
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Post: #2
RE: HIV kao lijek protiv raka?

Za 10 godina... Sta li ce tad biti...



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12-08-2011 01:42 AM
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stale Offline
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Post: #3
Re: HIV kao lijek protiv raka?

Sjajna vest. samo mi je zastrasujuce to sto nisu mogli da dobiju pare za istrazivanje. To govori da vecini i nije u interrsu da se bolest izleci vec da se od ljudi izvlace pare dok ne umru.



To permit irresponsible authority is to sow disaster; to hold a man responsible for anything he does not control is to behave with blind idiocy.

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12-08-2011 08:43 AM
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doktor Offline
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RE: HIV kao lijek protiv raka?

Naravno,farmaceutske kuce su neopevane dzukele koje samo zele da zaradjuju na pacijentima.Da samo znate koliko njihovih komercijalista dolazi kod nas i vrbuju moje kolege (cak su i mene probali da vrbuju) da nepotrebno prepisuju lekove pacijentima koje bas ta farmaceutska kuca proizvodi ili distribuira.Evo juce sam video studiju koja kaze da zbog takvog ponasanja u Srbiji farmaceutske kuce su zaradile u protekloj fiskalnoj godini preko 10 MILIONA evra pa vi vidite.UZAS! sadface
A sto se tice ovog istrazivanja ja sam ga pratio neko vreme preko PUBMED sajta i rezultati bas obecavaju.Nadam se da ce biti napretka na tom polju jos vise



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12-08-2011 10:49 AM
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ultranova Offline
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Post: #5
RE: HIV kao lijek protiv raka?

Pa to ti je bolje "liječiti" i pare uzimati nego izliječiti...I da i ovoga ima što doktor kaže, strašno...


12-08-2011 12:33 PM
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Mrakoslava Offline
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Post: #6
RE: HIV kao lijek protiv raka?

[Image: cuda-uropatije.jpg]

Alo bre nemate vi nista pojma ja prodajem zivinu vodicu leci pankreas, rak, zucne kesice, prostate, erektilne disfunkcije, bolove u stopalima.... :P
Salu na stranu - zalosno je koliko se malo ulaze u medicinu i related istrazivanja...


(This post was last modified: 12-08-2011 01:15 PM by Mrakoslava.)
12-08-2011 01:10 PM
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doktor Offline
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RE: HIV kao lijek protiv raka?

Meni nekada pripadne muka od svega toga.Hvala bogu ima nas koji jos valjamo i koji smo nesto znanja poneli sa fakulteta.Evo npr ja sam tek sada usao u neko istrazivanje vezano za uticaj zracenja novih radiolosko-dijagnostickih aparata koje smo dobili na zive organizme.Nisam mogao da verujem da se u Srbiji vrse naucna istrazivanja na tu temu

@Mrakoslava ovo sto si nasla je genijalno,tipican prikaz gluposti koje prolaze kod nas.Vidjao sam jos gore stvari od kojh se prevrnes od smeha biggrin



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(This post was last modified: 12-08-2011 10:47 PM by doktor.)
12-08-2011 10:44 PM
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Black_Waltz Offline
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Post: #8
RE: HIV kao lijek protiv raka?

Gosn Doktore,ta tabla stoji pored Futoške pijace u Novom Sadu već nekoliko godina.



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13-08-2011 12:27 AM
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Mrakoslava Offline
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Post: #9
RE: HIV kao lijek protiv raka?

@Black_Waltz Mozda covek nije iz NSbiggrin
@doktor Uuu gde radite istrazivanje?

Ontopic: rak je vrlo profitabilna bolest Smile U Amerikama hemoterapije i zracenje kostaju kao sam djavo...


13-08-2011 02:32 AM
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grimlord Offline
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Post: #10
RE: HIV kao lijek protiv raka?

Samo da smo mi zhivi i zdravi. Kakvi novci, kakvi bakrachi, nishta nije bitnije od zdravlja. Yep, bash sam pravu mudrost izrekao. XD Ali shta tju, to mi prvo pada na pamet, kada chitam ovako neshto.

Verovatno postoje lekovi za mnogo toga, koji nisu dostupni shiroj populaciji. Da, ja verujem u teorije zavere... Smile Ali svaki napredak na polju medicine je sjajna vest. Nadam se da tje iskoreniti sve ove opake bolesti koje muche chovechanstvo dekadama. Nebrojeni su oni kojima bi to znachilo vishe od svega na svetu.


13-08-2011 07:45 AM
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doktor Offline
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RE: HIV kao lijek protiv raka?

Nisam iz Novog Sada,iz Bg-a sam mada dosta cesto svracam u Ns i prolazim pored Futoske pijace ali nisam je izvalio.U svakom slucaju 2 bambija za Mrakoslavu biggrin

@Mrakoslava Istrazivanja se rade u okviru instituta.Imamo svoju tzv "shtalu" gde drzimo primerke.Zivotinjice zive u odlicnim uslovima i odlicno se hrane.Kao u filmovima samo jos bolje i humanije.Najomiljeniji su mi misevi sa onim svojim albino crvenim okicama biggrin

@Grimlord Nazalost danas je samo bitna cena proizvodnje i koliko ce neko da zaradi.Npr tek pre 10-ak godina su poceli da primenjuju lekove koji pacijentima od HIV-a sa normalnim primanjima znacajno produzavaju zivot a ti lekovi su postojali minimum 7 godina pre toga.Medzik Dzonson je ocit primer



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13-08-2011 10:01 AM
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Black_Waltz Offline
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Post: #12
RE: HIV kao lijek protiv raka?

Gosn Doktore,nemojte spominjati albino miševe sa crvenim okicama - Mrakoslavi se odmah javi neki primalni osećaj svih biologa još sa početka istorije sveta te una brzo dograbi oštar predmet i krene da seca Lol



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13-08-2011 12:03 PM
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Mrakoslava Offline
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Post: #13
RE: HIV kao lijek protiv raka?

Jel to neki omaz na moje slike disekcija?biggrinbiggrinbiggrin

Albino misevi su cutebiggrin
Cula sam da je prilicno lose stanje ovde sto se istrazivanja tice. (nije kao da ocekujem da neko u srbiji finansira takve stvari pored grand televizije).
Bila sam proslog meseca kod nas u Kamenici na institutu na onkologiji kao deo neke radionice na kongresu, malo me je deprimiralo sto je sve tako... sta ja znam, neobecavajuce:S Imam osecaj kao da doktori rade za dzabe, a da drugu polovinu koja ne radi za crkavicu nije briga. Objasnjavao nam je covek kako radi brahiterapiju itd i bilo je jako zanimljivo ali ujedno i potuzno sto se ne primenjuje gomila stvari:S


13-08-2011 02:30 PM
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doktor Offline
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RE: HIV kao lijek protiv raka?

Mrakoslava vidi se da si u bransi i da razumes sta se desava.Koji si faks zavrsila?
Jedina istrazivanja koja se rade ozbiljno su nazalost pri medicinskom faksu u Beogradu i nesto malo pri institutu Batut.Ova Bolonjska deklaracija je bas unazadila i ova kakva takva istrazivanja kod nas tako da ne znam da li ce biti ikakvog napretka na tom polju.Ovo sto ja radim je propisano zakonom zbog nove opreme koja je stigla inace ne bi se oni hvatali toga da ne moraju.Pre bi isli na neko letovanje od tih para koje im da ministarstvo ili bi kupili kola i sl.Veliki broj mojih kolega ukljucujuci i mene radimo bukvalno za dzabe a ove druge kolege necu ni da komentarisem.Bice im dovoljna kazna kada se nadju u crnoj hronici u nekim novinama.
Mislim da ce napredak u medicini doci onda kada se nadje ozbiljan ministar koji ce da propise redovne ispite za licencu.Svake godine moras da polazes ispit i ako si ostvario minimum radnog ucinka znaces da resis sva pitanja i licenca ti ostaje.A ako si blejao i nisi radio skloni se,ima onih koji zele da rade i koji znaju svoj posao biggrin

P.S. Ja sam inace ponosni vlasnik jedne cincile a imao sam i 2 bela misa koji su doziveli poznu starost biggrin



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(This post was last modified: 13-08-2011 04:40 PM by doktor.)
13-08-2011 04:34 PM
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Mrakoslava Offline
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RE: HIV kao lijek protiv raka?

Nisam zavrsila faks student samSmile Zavrsicu molekularnu biologiju... Ili nesto slicno ako ne nastavim u Novom Sadu.
Uh potpuno se slazem da treba da se napravi neki sistem vezan za licence... Ne znam sad koliko je to prakticno raditi ispit svake godine, al neka strozija kontrola svakako je neophodna. Mislim sramota je da kod nas ljudi odu da operisu culjeve i umru od sepse:S
Haha dostigli poznu starostbiggrin


13-08-2011 11:03 PM
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